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KMID : 0985420220440010048
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Laboratory Medicine and Quality Assurance
2022 Volume.44 No. 1 p.48 ~ p.54
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Application of Geometric Mean Criteria for Anti-Blood Group Antibody Proficiency Testing in the Korean External Quality Assurance Program
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Yang John Jeong-Seok
Youk Hee-Jeong
Chung You-Sun
Kim Hyung-Suk
Hwang Sang-Hyun
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Abstract
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Background: The geometric mean criteria (GC) is an alternative for assessing proficiency testing (PT) acceptability. A recent study applied GC to the PT results provided by the College of American Pathologists. We assessed the feasibility of using GC for anti-blood group antibody titration testing (ABT) in the Korean PT program.
Methods: The results of the ABT performed in 2019 were reviewed using GC. GC was calculated as geometric mean (GM)±multiples of geometric standard deviation (GSD). The number of acceptable results obtained using GC was compared to that of the conventional mode criteria (MC, mode±1 second). Only the results with 30 or more peer group responses were included in the analyses.
Results: A total of 27 PT results (anti-A: 13, anti-B: 14) were analyzed. The acceptable proportions from MC were 82.9%?100.0% for anti-A and 76.2%?100.0% for anti-B. The GC criteria yielded acceptable results of 46.9%?97.6% (1 GSD), 88.6%?100.0% (2 GSD), and 97.3%?100.0% (3 GSD) for anti-A. For anti-B, 1 GSD, 2 GSD, and 3 GSD criteria resulted in 44.7%?90.6%, 90.6%?100.0%, and 97.4%?100.0%, respectively. In general, acceptable results using MC were found to be distributed between 1 GSD and 2 GSD.
Conclusions: The GC can be used as an alternative assessment criterion with a more robust statistical rationale. While conventional MC struggles with representing the central tendency of data, GC provide better visualization of the central tendency.
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KEYWORD
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Laboratory proficiency testing, Geometric mean, Mode, Acceptability
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